Silver Nanoparticle-Infused Hydrogel Systems with Cell Wall Synthesis Inhibitors: A Dual-Action Strategy for Effective Wound Infection Control

A significant clinical care challenge is infection management in wounds, particularly in light of the growing incidence of bacteria resistant to antibiotics. Innovative wound-healing materials have prompted the incorporation of cutting-edge technology, such hydrogels coated with silver nanoparticles (AgNPs), which provide dual-action antibacterial tactics. The broad-spectrum antibacterial qualities of silver nanoparticles cause structural damage and growth inhibition by interacting with bacterial cell membranes and releasing silver ions. By targeting the development of bacterial cell walls, cell wall synthesis inhibitors further reduce bacterial growth and improve the overall effectiveness of treatment. Additional advantages of incorporating these agents into the hydrogel matrix include moisture retention, controlled medication release, and the capacity to adapt to wound surfaces, all of which support the development of a favourable environment for tissue regeneration. Additionally, the hydrogels may release antibiotics and silver nanoparticles locally and continuously, promoting wound healing and avoiding infections. The mechanisms of cell wall synthesis inhibitors and silver nanoparticles in wound infection prevention are examined in this study, emphasizing how they may work together to promote wound healing. By tackling the problems of infection and encouraging quicker, more effective healing results, such sophisticated systems hold great potential for the treatment of contemporary wounds.