Bioinformatic Approach to Cross-Reactivity Between Dust Mites and Scabies Mites: Clinical and Molecular Implications

Cross-reactivity between house dust mites and scabies mites is a clinically significant but often underestimated phenomenon that can complicate both the management of respiratory allergies and the diagnosis of parasitic infections such as scabies. The antigenic properties shared between these species are supported by a bioinformatic analysis we conducted, as well as by proteomic and immunological studies reported in the literature, which highlight structurally similar proteins capable of inducing cross-immune responses. This article provides a comprehensive analysis of the main allergens involved, focusing on the molecular mechanisms underlying cross-reactivity, its clinical implications, and potential diagnostic and therapeutic applications.