Frequency Analysis of PON1 Gene Polymorphism in Patients with Coronary Artery Stenting

Background/Objectives: Cardiovascular disease (CVD) is the leading cause of death worldwide, primarily owing to plaque formation in the coronary artery, which causes stenosis. One of the important causes in the development of atherosclerosis is systemic oxidative stress, which can be altered by serum paraoxonase 1 (PON1), one of the enzymes located on the high-density lipoprotein (HDL) particles. Methods: the study design used in this clinical and genetic investigation case-control. A total of 257 persons were investigated, including 149men and 108 women. The subjects were the indigenous population of Kazakh nationality of both sexes aged 45-80 years, living in the region of Karaganda, hospitalized in city-level clinics. The study was performed in the Laboratory of collective use of «Karaganda Medical University» non-commercial joint-stock company in Karaganda. The genetic research was conducted at the Laboratory of genomic and personalized medicine, National Laboratory Astana, Nazarbayev University, Kazakhstan. Results: The results show that traditional risk factors for atherosclerosis and CHD, such as dyslipidemia, hypertension, smoking increased body mass index does not always make a significant contribution to the development of cardiovascular complications after PCI in patients with CHD. According to the genotype study, the polymorphism of the PON1-rs854560 [L55M] a/a homozygous allele was detected in 54.5 % of the examined individuals. Conclusions: Thus, the polymorphism of the PON1 gene, which encodes an enzyme of the body's antioxidant defense system, correlates with the development of CHD.