Modeling Techniques and Boundary Conditions in Abdominal Aortic Aneurysm Analysis: Latest Developments in Simulation and Integration of Machine Learning and Data-Driven Approaches

Research on abdominal aortic aneurysm (AAA) primarily focusses on developing a clear understanding of the initiation, progression, and treatment of AAA through improved model accuracy. High-fidelity hemodynamic and biomechanical predictions are essential for clinicians to optimize preoperative planning and minimize therapeutic risks. Computational fluid dynamics (CFD), finite element analysis (FEA) and fluid-structure interaction (FSI) are widely used to simulate AAA hemodynamics and biomechanics. However, the accuracy of these simulations depends on utilization of realistic and sophisticated boundary conditions (BCs), which are essential for properly integrating the AAA with the rest of the cardiovascular system. Recent advances in machine learning (ML) techniques have introduced faster, data-driven surrogates for AAA modeling. These approaches can accelerate segmentation, predict hemodynamics and biomechanics, and assess disease progression. However, their reliability depends on high-quality training data derived from CFD and FEA simulations, where BC modeling plays a crucial role. Accurate BCs can enhance ML predictions, increasing the clinical applicability. This paper reviews existing BC models, discussing their limitations and technical challenges. Additionally, recent advancements in ML and data-driven techniques are explored, discussing current state, future directions, common algorithms and limitations.