Rejuvenate Right and Anatomically Aligned – a Prospective Study on Safety and Satisfaction with Hyperdiluted PLLA Injections into the Temples and Neck

Background: Injectable biostimulators, particularly Poly-L-Lactic Acid (PLLA), have significantly advanced aesthetic medicine by promoting collagen production for skin rejuvenation and volume restoration. This study investigates the efficacy and safety of hyperdiluted PLLA injections in the temples and neck, advocating for customized concentrations to enhance results and minimize risks Objective: To evaluate the clinical efficacy and safety profile of hyperdiluted PLLA injections in the neck and temple region. Materials and methods: All patients were treated with injections of hyperdiluted PLLA (Rennova Elleva®) in the neck and temple region. All patients underwent six-monthly clinical evaluations and kept self-reporting diaries to record any adverse effects during the first 30 days. Patient satisfaction was assessed using the Subject Global Aesthetic Improvement Scale (S-GAIS) on days 90 and 150 post-injection. Results: The study included 16 female patients with a mean age of 50.19 (11.3) years and a mean of BMI: 22.80 (2.2) kg/m². Eight patients (50%) reported mild to moderate injection site reactions, such as redness, pain, hardening, swelling, lumps, bruises, and skin discoloration, with most symptoms resolving within a few days. Clinically, no major adverse events were noted. On post-injection day 90, the average GAIS was 3.1 ± 0.86, indicating an overall “improved” aesthetic appearance, which improved to 2.5 ± 0.97 by day 150 (p=0.12). Conclusion: Hyperdiluted PLLA injections are a safe and effective treatment for facial rejuvenation in the temple and neck areas, offering sustained patient satisfaction and minimal adverse effects. The tailored injection technique, which accounts for unique anatomical characteristics, maximizes results and minimizes complications, highlighting the importance of customized treatment strategies in aesthetic medicine.