Research Advances in Titanium Plate Surface Modifications for Clinical Osteogenesis Applications: A Comprehensive Review

  1. Randy Bachelard Nziengui Raby
  2. Guy-Armel Bounda
  3. Kelvin Stefel Lebila Moutsi
  4. Idriss Francois Ntsame Allogo
  5. Justia Varaine Mengue Obame
  6. Monique Lauriane Adou Ovolo
  7. Kwensy Djoyce Ondo
  8. Geraldine Esther Awakossa
  9. Kiny-Binyumbe Doukaga
  10. Rosanna Tryphene Massounga Mayombo
  11. Dally Bea Mengue Medzang
  12. Marie Mical Tsamba Mpira
  13. Maywann Bengono
  14. Ulrich Freddy Nziengui Mbadinga
  15. Maëlle Noémie Mengue Obame
  16. Noreen Teingue Dodo
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Abstract

Titanium and its alloys are indispensable in bone regeneration and implantology due to their superior biocompatibility and mechanical strength. This review synthesizes recent advances in titanium plate surface modifications for osteogenesis, focusing on innovative approaches in surface engineering—such as the integration of nanomaterials, bioactive coatings, and laser treatments—to enhance osseointegration, antibacterial properties, and implant durability. We conducted a systematic literature search (2010–2024) across PubMed, Web of Science, Scopus, and ScienceDirect to comprehensively capture high-quality studies in this field. Our critical assessment places these modifications within the context of improved clinical outcomes in orthopedic and reconstructive surgeries, addressing challenges of long-term stability, cost-effectiveness, and regulatory compliance. Overall, our comprehensive analysis provides valuable insights into current practices and outlines future research directions essential for optimizing implant performance, aligning with the scope of Challenges by presenting innovative solutions in the rapidly evolving field of biomaterials.

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  1. Version published to 10.20944/preprints202502.0627.v1