Serum Prolidase Activity in Silicosis and Its Relationship with Oxida-Tive Stress and Inflammation Markers

Background:This study aimed to evaluate the prognostic significance of serum prolidase ac-tivity in silicosis and to examine its relationship with oxidative stress and inflammatory param-eters. Methods: One hundred thirteen patients with silicosis, 70 workers with a history of exposure who did not develop the disease and 53 healthy volunteers of similar age and gender were included in the study. Serum levels of prolidase, superoxide dismutase, catalase, 8-hydroxy-2-deoxyguanosine, glutathione peroxidase, glutathione reductase, tumor necrosis factor α, fibroblast growth factor, interferon-gamma, and interleukins (IL) 1α and 1β were measured. Genetic damage was assessed by measuring 8-hydroxy-2'-deoxyguanosine in serum. Results: The difference was not statistically significant because serum prolidase activity was higher in the silicosis and silica-exposed group than in healthy controls.Serum superoxide dis-mutase and glutathione peroxidase levels were significantly lower in the exposure and silicosis groups compared to the control group. 8-hydroxy-2'-deoxyguanosine and tumor necrosis factor α, fibroblast growth factor, interferon-gamma, and IL-1α were significantly higher in the exposure and silicosis groups than in the control group. In individuals with high prolidase activity, both oxidative stress and inflammation parameters were high. Conclusion:The fact that serum prolidase activity is closely associated with inflammation, fibrosis, and oxidative stress in sili-cosis suggests that prolidase can be used in the early diagnosis and follow-up of silicosis. Early disease diagnosis is important for stopping exposure and taking preventive measures.