<p class="MDPI12title">A Scoping Review Of Neurological Manifestations Of Dengue Virus Infection Besides Cerebrovascular Disorders

Dengue virus (DENV) infection is a significant global public health concern, with its burden pre-dominantly felt in tropical and subtropical regions. While commonly associated with febrile ill-ness and systemic complications, neurological manifestations beyond cerebrovascular disorders are increasingly recognized but remain underexplored. This scoping review aims to synthesize the current understanding of non-cerebrovascular neurological manifestations of DENV infec-tion, including encephalitis, encephalopathy, myelitis, Guillain-Barré syndrome, acute dissemi-nated encephalomyelitis (ADEM), and neuropathies. A narrative search of peer-reviewed litera-ture was conducted to identify studies reporting clinical presentations, pathophysiological mechanisms, diagnostic approaches, and treatment strategies for these manifestations. Findings suggest that neurological complications often arise from direct viral neuroinvasion, im-mune-mediated mechanisms, or systemic complications such as metabolic disturbances. Key symptoms include altered mental status, seizures, focal neurological deficits, and peripheral nerve involvement. Neuroimaging and cerebrospinal fluid analysis are essential tools for diag-nosis, though challenges remain in differentiating dengue-associated manifestations from other tropical infections. Management is primarily supportive, with corticosteroids and immunomod-ulators employed in immune-mediated conditions. This review underscores the need for height-ened clinical awareness and further research to improve diagnostic accuracy and therapeutic outcomes for dengue-related neurological disorders. Understanding these manifestations is cru-cial for reducing morbidity and improving patient care in endemic regions.