Clinical course and risk factors for recurrence of positive SARS-CoV-2 RNA: a retrospective cohort study from Wuhan, China

  1. Jie Chen
  2. Xiaoping Xu
  3. Jing Hu
  4. Qiangda Chen
  5. Fengfeng Xu
  6. Hui Liang
  7. Nanmei Liu
  8. Hengmei Zhu
  9. Jinlong Lan
  10. Lan Zhou
  11. Jiajun Xing
  12. Ning Pu
  13. Zhigang Cai

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Abstract

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  1. Version published to 10.18632/aging.103795
  2. ScreenIT

    SciScore for 10.1101/2020.05.08.20095018: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was approved by the Research Ethics Committee of Guanggu Branch of Hubei Province Maternity and Childcare Hospital and was granted with a waiver of informed consent from study participants.
    Consent: This study was approved by the Research Ethics Committee of Guanggu Branch of Hubei Province Maternity and Childcare Hospital and was granted with a waiver of informed consent from study participants.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableHypoproteinaemia was defined as blood albumin of less than 25 g/L, coagulopathy was defined as a 3-second increase in prothrombin time or a 5-second increase of activated partial thromboplastin time, and hyperuricemia was defined as blood trioxypurine greater than 420 umol/L (male) or 360 umol/L (female).

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    All statistical analyses were performed using the SPSS v21.0 software (IBM Corporation, Armonk, NY, USA), and figures were plotted by GraphPad Prism 8.0 software (GraphPad Software, La Jolla, CA, USA).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)
    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations: This study has a few notable limitations. First, this study was conducted at a single-center hospital. As such, there may be an element of selection bias where identifying factors may influence the clinical outcomes. A larger cohort study of patients with COVID-19 pneumonia from different institutions nationwide or worldwide would help to further define the clinical characteristics and risk factors of recurrence. Second, only multipoint of throat-swab specimens were performed for patients in this study. Thus the chance of false negative results is still possible. Multisite sampling could be collected for RT-PCR detection, such as the fecal SARS-CoV-2 RNA test, particularly in patients with gastrointestinal symptoms.33

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.05.08.20095018 on medRxiv