Material-Space-Flow (MSF): A Meta-Model for Human Body System Modeling

This paper proposes the Material-Space-Flow (MSF) model, a ternary framework designed to provide a unified, cross-disciplinary analytical framework for understanding both normal function and pathological dysregulation of the human pressure system. It conceptualizes the body as an intelligent system whose emergent properties arise from the dynamic interactions among Material (the mechanical properties of tissues), Space (anatomical compartments and fascial interfaces), and Flow (the integrated transport of energy, information, force, and mass).

This paper is the first to systematically articulate the definitions and connotations of these three core elements and their synergistic mechanisms, which are fundamental to maintaining systemic pressure equilibrium, enabling efficient transport, and facilitating adaptive, intelligent regulation. By establishing the pressure gradient (defined as the spatial rate of pressure change,Δ P /Δ S ) as the central observable and introducing its spatiotemporal duality as an evaluative framework, this model transcends the limitations of conventional approaches. It thereby provides a powerful theoretical tool for systematically explaining the intrinsic unity of phenomena ranging from localized dysfunction to systemic failure.