SARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent?
This article has been Reviewed by the following groups
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2020.05.04.20084657: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The protocol was considered a quality improvement project and granted exemption by the VA Connecticut Research Office and deemed that review by the VA Connecticut Investigational Review Board or R&D Committee was not needed since the objective was optimization of testing supplies.. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following …SciScore for 10.1101/2020.05.04.20084657: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The protocol was considered a quality improvement project and granted exemption by the VA Connecticut Research Office and deemed that review by the VA Connecticut Investigational Review Board or R&D Committee was not needed since the objective was optimization of testing supplies.. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are several limitations to our study. Our sample size is small and needs to be confirmed in future larger studies. Furthermore, we used two proprietary testing formulations. Whether this is generalizable to other formulations of viral and non-viral sampling systems is not known. Ideally, we would have liked to test each sample on multiple platforms looking for concordance between several testing modalities, as it is conceivable that inhibitory substances may be present in nasal materials or different transport media. However, due to the ongoing relative shortage of available reagents, we could not justify this for this quality improvement project. Additionally, while our study was conducted only in Veterans, we do not believe there should be a difference in test results between Veterans and non-Veterans for the positive or negative predictive value of testing for SARS-CoV-2 infection. In addition to its tremendous physical and emotional toll, infection caused by SARS-CoV-2 has stressed supply chains. While some may have used typical MRSA swabs when there have been shortages of viral swabs, heretofore there has been little evidence of their testing characteristics. We found a high rate of concordance in test results between COPAN ESwabs ® 480C in Amies solution and swabs in viral media. Clinicians and laboratories should feel better informed and assured that using COPAN ESwabs ® 480C to help in the diagnosis of COVID-19 is acceptable in resource-limited settings.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
