Encephalopathies Associated With Severe COVID-19 Present Neurovascular Unit Alterations Without Evidence for Strong Neuroinflammation
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SciScore for 10.1101/2020.11.01.20217497: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics: This study was approved by the Canton de Vaud Ethical Committee (CER-VD) in the frame of CORO-NEURO study (authorization n° 2020-01123) and COOLIN-BRAIN study (authorization n°2018-01622).
Consent: All patients included in this study signed specific informed consent.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Patients with a nasopharyngeal swab positive for SARS-CoV-2 detection by RT-PCR and/or a serology test for anti-SARS-CoV-2 antibodies together with clinical presentation of SARS-CoV-2 infection were defined as COVID-19 patients … SciScore for 10.1101/2020.11.01.20217497: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics: This study was approved by the Canton de Vaud Ethical Committee (CER-VD) in the frame of CORO-NEURO study (authorization n° 2020-01123) and COOLIN-BRAIN study (authorization n°2018-01622).
Consent: All patients included in this study signed specific informed consent.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Patients with a nasopharyngeal swab positive for SARS-CoV-2 detection by RT-PCR and/or a serology test for anti-SARS-CoV-2 antibodies together with clinical presentation of SARS-CoV-2 infection were defined as COVID-19 patients (25 patients). anti-SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Graphical representation and statistical analysis: Graphical representation and statistics were generated using PRISM software (version 8.1.2, GraphPad software, La Jolla, Ca, USA). PRISMsuggested: (PRISM, RRID:SCR_005375)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Heatmaps and k clustering were made using ClustVis web-based tool 18. ClustVissuggested: (ClustVis, RRID:SCR_017133)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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