Association of COVID-19 with neurodegenerative and neurological disorders in vaccinated and unvaccinated people
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Introduction
COVID-19 has been linked to neuropathology, neurological symptoms, and diagnoses of neurological illnesses. Evidence regarding the long-term impact of COVID-19 on neurodegenerative and neurological disorders is still limited.
Methods
We investigated associations of COVID-19 with neurodegenerative and neurological disorders by vaccination status in both hospitalised patients and the general population in the largest and longest study to date. We used OpenSAFELY-TPP to access linked electronic health records from 18.3 million adults registered with English GPs. We defined three cohorts with up to 5.5 years follow-up: pre-vaccination (exposed to COVID-19 January 2020-June 2021), and vaccinated and unvaccinated (exposed June-December 2021). We estimated adjusted hazard ratios (aHRs) comparing the incidence of cognitive impairment and dementia after diagnosis of COVID-19 with before or without COVID-19. We also studied Parkinson’s disease, restless leg syndrome, rapid eye movement sleep disorder, motor neuron disease, multiple sclerosis, and migraine.
Results
Incidence of most outcomes was elevated during weeks 0-4 after COVID-19 (cognitive impairment/dementia aHRs; pre-vaccination: 4.02 (3.74-4.32)/5.05 (4.63-5.52), vaccinated: 2.24 (2.05-2.45)/2.05 (1.77-2.37), unvaccinated: 4.38 (3.45-5.55)/8.69 (6.13-12.32)). Incidence remained elevated up to 4 years after COVID-19, especially in those hospitalised with COVID-19 (cognitive impairment/dementia aHRs; pre-vaccination: 1.49 (1.35-1.64)/ 1.39 (1.21-1.60), vaccinated: 1.27 (1.04-1.54)/1.32 (1.02-1.71), unvaccinated: 1.55 (1.11-2.16)/1.48 (1.00-2.20)).
Conclusion
Incidence of cognitive impairment and dementia were elevated shortly after COVID-19. Incidence of cognitive impairment remained elevated in the longer term, particularly among unvaccinated individuals and/or those hospitalised with COVID-19. These patients may require additional assessment during routine care to evaluate persistent or new cognitive concerns.
Article activity feed
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It seems that the health authorities have brain damage. Introduction COVID-19 has been linked to neuropathology, neurological symptoms, and diagnoses of neurological illnesses. Evidence regarding the long-term impact of COVID-19 on neurodegenerative and ne www.medrxiv.org/content/10.6...
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The largest and longest study to date, using health records from 18.3 million adults, found COVID infection was linked to higher risks of cognitive impairment and dementia. Cognitive impairment risk remained elevated for up to 4 years, especially among unvaccinated and hospitalised patients.
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It’s never a bad time to mask and get vaccinated www.medrxiv.org/content/10.6...
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Here's how fucked we are Incidence of cognitive impairment and dementia were elevated shortly after COVID-19. Incidence of cognitive impairment remained elevated in the longer term, particularly among unvaccinated individuals and/or those hospitalised with COVID-19. www.medrxiv.org/content/10.6...
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🧠 Daily Feed of Brain Damage 🧠 www.medrxiv.org/content/10.6...
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たいへん勉強になりました。 （プレプリント） www.medrxiv.org/content/10.6...
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This is circulating among the known alarmists. Association of COVID-19 with neurodegenerative and neurological disorders in vaccinated and unvaccinated people It is a preprint, and as shown previously, confounders may play havoc. www.medrxiv.org/cont... 1/7
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COVID-19-Erkrankung erhöht sein kann; dies gilt vor allem für Personen, die zum Zeitpunkt ihrer COVID-19-Diagnose ungeimpft waren.« www.medrxiv.org/content/10.6...
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ワクチン接種者および未接種者における、COVID-19と神経変性疾患・神経疾患との関連 www.medrxiv.org/content/10.6... ChatGTP6,素人質問 chatgpt.com/share/6aea9e...
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Direct link to the preprint mentioned in the post above: Association of COVID-19 with neurodegenerative and neurological disorders in vaccinated and unvaccinated people (Nov 1, 2026) www.medrxiv.org/content/10.6... [ FREE PDF available ]
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Dementia … Do you feel demented? “Incidence remained elevated up to 4 years after COVID-19, especially in those hospitalised with COVID-19 (cognitive impairment/dementia aHRs” www.medrxiv.org/content/10.6...
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Quelle www.medrxiv.org/content/10.6...
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18 Millionen #Covid Kohorte in UK, 5,5y follow-up vor #Impfung ist das Risiko einer kognitiven Beeinträchtigung im Jahr 1–2 +20% 3–4 +13 % 4–5,5 +29 %, ohne Krankenhausaufenthalt +28 % Ungeimpfte Delta -4 Jahren +36–56% Hört man deswegen von #Ungeimpften häufiger Müll 😉?
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The pro-disease crowd is something. Their brains must be compromised from a prior infection. www.medrxiv.org/content/10.6...
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University of Bristol researchers studied 18.3 million adults and found cognitive impairment remained elevated for at least 5 years after COVID-19. Risks were generally higher in unvaccinated and hospitalized patients. www.medrxiv.org/content/10.6...
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Association of COVID-19 with neurodegenerative and neurological disorders in vaccinated and unvaccinated people #NeuroDegeneration 🧪🧠 https://www.medrxiv.org/content/10.64898/2026.10.30.26366919v1
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