Gastroenterological and hepatic manifestations of patients with COVID-19, prevalence, mortality by country, and intensive care admission rate: systematic review and meta-analysis
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Abstract
Patients infected with the SARS-CoV-2 usually report fever and respiratory symptoms. However, multiple gastrointestinal (GI) manifestations such as diarrhoea and abdominal pain have been described. The aim of this study was to evaluate the prevalence of GI symptoms, elevated liver enzymes and mortality of patients with COVID-19.
Methods
A systematic review and meta-analysis of published studies that included a cohort of patients infected with SARS-CoV-2 were performed from 1 December 2019 to 15 December 2020. Data were collected by conducting a literature search using PubMed, Embase, Scopus, and Cochrane according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We analysed pooled data on the prevalence of individual GI symptoms and elevated liver enzymes and performed subanalyses to investigate the relationship between GI symptoms/elevated liver enzymes, geographical location, mortality, and intensive care unit (ICU) admission.
Results
The available data of 78 798 patients positive for SARS-CoV-2 from 158 studies were included in our analysis. The most frequent manifestations were diarrhoea (16.5%, 95% CI 14.2% to 18.4%), nausea (9.7%, 95% CI 9.0% to 13.2%) and elevated liver enzymes (5.6%, 95% CI 4.2% to 9.1%). The overall mortality and GI mortality were 23.5% (95% CI 21.2% to 26.1%) and 3.5% (95% CI 3.1% to 6.2%), respectively. Subgroup analysis showed non-statistically significant associations between GI symptoms/elevated liver enzymes and ICU admissions (OR=1.01, 95% CI 0.55 to 1.83). The GI mortality was 0.9% (95% CI 0.5% to 2.2%) in China and 10.8% (95% CI 7.8% to 11.3%) in the USA.
Conclusion
GI symptoms/elevated liver enzymes are common in patients with COVID-19. Our subanalyses showed that the presence of GI symptoms/elevated liver enzymes does not appear to affect mortality or ICU admission rate. Furthermore, the proportion of GI mortality among patients infected with SARS-CoV-2 varied based on geographical location.
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SciScore for 10.1101/2020.10.29.20207167: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization The inclusion criteria were (1) study type: case reports/case series (including chart reviews), prospective/retrospective cohort studies, case control studies, cross sectional studies and randomized controlled trials; (2) patients population: Adults patients with COVID-19; inpatient or outpatient setting and (3) Outcome measured: At least one GI manifestation reported and LFT abnormality, defined as any value above the normal upper limit. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Search strategy: A systematic review was conducted … SciScore for 10.1101/2020.10.29.20207167: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization The inclusion criteria were (1) study type: case reports/case series (including chart reviews), prospective/retrospective cohort studies, case control studies, cross sectional studies and randomized controlled trials; (2) patients population: Adults patients with COVID-19; inpatient or outpatient setting and (3) Outcome measured: At least one GI manifestation reported and LFT abnormality, defined as any value above the normal upper limit. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Search strategy: A systematic review was conducted using Pubmed, Scopus, Cochrane, and Embase databases. Pubmedsuggested: (PubMed, RRID:SCR_004846)Cochranesuggested: (Cochrane Library, RRID:SCR_013000)Embasesuggested: (EMBASE, RRID:SCR_001650)Data extraction was performed using Microsoft excel. Microsoft excelsuggested: (Microsoft Excel, RRID:SCR_016137)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: Most of the studies we base our analyses on are observational, single arm cohorts. The lack of control groups and comparison arms can lead to bias due to confounding. Also, our subanalyses might have been affected by small sample sizes. Additionally, regarding fatality rate among COVID-19 patients, most of the studies did not differentiate between the GI symptoms and LFTs abnormalities when performing head to head comparison.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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