The Global and Local Distribution of RNA Structure throughout the SARS-CoV-2 Genome

  1. Rafael de Cesaris Araujo Tavares
  2. Gandhar Mahadeshwar
  3. Han Wan
  4. Nicholas C. Huston
  5. Anna Marie Pyle

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Abstract

The RNA genome of SARS-CoV-2 is among the largest and most complex viral genomes, yet its RNA structural features remain relatively unexplored. Since RNA elements guide function in most RNA viruses, and they represent potential drug targets, it is essential to chart the architectural features of SARS-CoV-2 and pinpoint regions that merit focused study.

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  1. Version published to 10.1128/jvi.02190-20
  2. ScreenIT

    SciScore for 10.1101/2020.07.06.190660: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Z-score frequency distributions for SARS-CoV-2, HCV, West Nile Virus and the composite of human mRNAs were calculated on GraphPad Prism.
    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)
    The statistical significance of the overlap between both methods was evaluated on Matlab by running simulations of randomly distributed elements in both groups.
    Matlab
    suggested: (MATLAB, RRID:SCR_001622)

    Results from OddPub: Thank you for sharing your code and data.

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • No conflict of interest statement was detected. If there are no conflicts, we encourage authors to explicit state so.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  3. Version published to 10.1101/2020.07.06.190660v1 on bioRxiv