The Evolution Mechanism with Protein Structure and Function and the Origin of SARS CoV-2
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Over the last few decades, novel viruses that present severe health risks worldwide. The SARS CoV-2 virus, formerly known as a novel coronavirus, broke out in Wuhan (China) and caused major morbidity and mortality globally. Confirmation of intermediate hosts is essential to prevent further spread of the epidemic. The emergence of COVID-19 has triggered many works aimed at stduy of the evolution and identifying the animal intermediate potentially involved in the transmission of SAR SCoV-2 to humans. This study focuses on comparisons of the SARS RNA- dependent RNA polymerase (RDRP) enzyme coding RNA sequences within and between SARS-CoV‐2 and SARS‐CoV, bat SARS‐like CoV, and other coronaviruses, which are helpful for evolutionary analysis to study the evolution mechanism and finding the possible virus reservoirs and the origin of COVID − 19.
