Multicenter Postimplementation Assessment of the Positive Predictive Value of SARS-CoV-2 Antigen-Based Point-of-Care Tests Used for Screening of Asymptomatic Continuing Care Staff
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Abstract
Frequent screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among asymptomatic populations using antigen-based point-of-care tests (APOCTs) is occurring globally with limited clinical performance data. The positive predictive value (PPV) of two APOCTs used in the asymptomatic screening of SARS-CoV-2 among health care workers (HCWs) at continuing care (CC) sites across AB, Canada, was evaluated. Between 22 February and 2 May 2021, CC sites implemented SARS-CoV-2 voluntary screening of their asymptomatic HCWs. On-site testing with Abbott Panbio or BD Veritor occurred on a weekly or twice-weekly basis.
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SciScore for 10.1101/2021.06.22.21259345: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Facilities were assigned (based on availability, oversight, and preference) to use either the Panbio COVID-19 Antigen Rapid Test (Abbott Laboratories, Chicago, USA) or the Veritor COVID-19 Rapid Antigen Test (Becton, Dickson, and Company, Franklin Lakes, USA), herein referred to as APOCT. Abbott Laboratoriessuggested: NoneData were tabulated in Microsoft Excel. Microsoft Excelsuggested: (Microsoft Excel, RRID:SCR_016137)Statistical analysis was conducted using StatPlus ( StatPlussuggested: (StatPlus Mac, …SciScore for 10.1101/2021.06.22.21259345: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Facilities were assigned (based on availability, oversight, and preference) to use either the Panbio COVID-19 Antigen Rapid Test (Abbott Laboratories, Chicago, USA) or the Veritor COVID-19 Rapid Antigen Test (Becton, Dickson, and Company, Franklin Lakes, USA), herein referred to as APOCT. Abbott Laboratoriessuggested: NoneData were tabulated in Microsoft Excel. Microsoft Excelsuggested: (Microsoft Excel, RRID:SCR_016137)Statistical analysis was conducted using StatPlus ( StatPlussuggested: (StatPlus Mac, RRID:SCR_014635)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The principal limitation of this study is that only positive APOCT tests were confirmed by rRT-PCR, and thus no other test parameters other than a PPV could be calculated. The data however, still confirms in a large asymptomatic HCW population, that APOCT has a low PPV. The major strengths of this study lie in the large number of tests performed, participating sites, and inclusion of two different APOCT platforms. The utility of screening asymptomatic individuals with COVID-19 APOCT is best determined by weighing the costs and benefits specific to each setting. With widespread vaccination increasing and disease prevalence falling, fewer positive test results are likely to be found among asymptomatic persons in the coming months (with a large proportion of them being false-positives), leading such endeavors to be quite costly from a materials and human resources perspectives for most health care systems. Therefore, it is important to reconsider the value and effectiveness of asymptomatic APOCT COVID-19 programs over the long term, especially in the context of increasing population immunity.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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