H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion
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Abstract
H3K9ac promotes basal progenitor amplification, neocortex expansion, and gyrification by activating Trnp1 expression in evolution.
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Excerpt
Kerimoglu et al. assess epigenetic differences between mouse and human cortical basal progenitors, pointing to H3K9 acetylation as a key epigenetic mechanism controlling basal progenitor amplification in the human developing cortex.
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