Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

  1. Arun C. Habermann
  2. Austin J. Gutierrez
  3. Linh T. Bui
  4. Stephanie L. Yahn
  5. Nichelle I. Winters
  6. Carla L. Calvi
  7. Lance Peter
  8. Mei-I Chung
  9. Chase J. Taylor
  10. Christopher Jetter
  11. Latha Raju
  12. Jamie Roberson
  13. Guixiao Ding
  14. Lori Wood
  15. Jennifer M. S. Sucre
  16. Bradley W. Richmond
  17. Ana P. Serezani
  18. Wyatt J. McDonnell
  19. Simon B. Mallal
  20. Matthew J. Bacchetta
  21. James E. Loyd
  22. Ciara M. Shaver
  23. Lorraine B. Ware
  24. Ross Bremner
  25. Rajat Walia
  26. Timothy S. Blackwell
  27. Nicholas E. Banovich
  28. Jonathan A. Kropski

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Abstract

Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.

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  1. Version published to 10.1126/sciadv.aba1972
  2. preLights

    Excerpt

    The application of single cell RNA sequencing (scRNAseq) approaches in the context of idiopathic pulmonary fibrosis (IPF) highlights dramatic remodelling of epithelial, stromal and vascular transcriptomes.

  3. Version published to 10.1101/753806v1 on bioRxiv