Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

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Abstract

Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.

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  1. Excerpt

    The application of single cell RNA sequencing (scRNAseq) approaches in the context of idiopathic pulmonary fibrosis (IPF) highlights dramatic remodelling of epithelial, stromal and vascular transcriptomes.