Gene regulatory networks controlling vertebrate retinal regeneration
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Abstract
Zebrafish can regenerate damaged retinal tissue, but mice cannot. Hoang et al. found that tracking changes in gene expression and chromatin accessibility upon injury revealed clues as to why retinal glial cells in zebrafish could generate new neurons but the same cell type in mice could not. In zebrafish, activated Müller glial cells shift into a proliferative phase, whereas in mice, a genetic network returns the glial cells to quiescence. A few transcription factors enforce quiescence in the mouse, and disruption of these allowed Müller glia to proliferate and generate new neurons after retinal injury.
Science , this issue p. eabb8598
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Excerpt
Fish can fully regenerate cells in the eye after an injury, the chick can do it partially, while mammals lack regenerative potential. The Blackshaw lab explores the pathways activated upon retinal injury in these species.
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