Growth-factor ligand functionalization enhances cellular and in vivo uptake of DNA nanodevices
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Epidermal Growth Factor (EGF) and Transforming Growth Factor beta (TGF-β) are two important classes of growth factor that regulates cell growth, cell proliferation, differentiation, immune responses, and extracellular matrix generation. Using a short peptide-based ligand coupled to DNA nanocages, we present the enhanced internalization of a receptor-mediated peptide-DNA nanocage. We used here tdDNA as a delivery vehicle. Our study in cellular and in vivo showed excellent internalization, cell growth, and inhibition. We expect that a tdDNA-modified receptor-binding peptides could become a valuable scaffold for use as a cellular programming and regenerative material.
