A measurement model to quantify systemic bacilli load in severe HIV-associated tuberculosis
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Systemic mycobacterial load is associated with outcome in HIV-associated tuberculosis but is poorly defined. We used latent variable modelling to characterise HIV-associated TB mycobacterial load. Mycobacterium tuberculosis detection tests on urine and blood, but not sputum, showed substantial co-variance, and were strongly correlated with host inflammation and mortality.
