Efficacy of Doxycycline as monotherapy or in combination with Levofloxacin in treating late-stage systemic anthrax in NHP
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Recent CDC guidelines for treating systemic anthrax recommend a combination of a Tetracycline (Minocycline or Doxycycline) with Meropenem or a Fluoroquinolone. These recommendations differ from the 2001 or 2014 updates, and in the absence of significant clinical data, rely mainly on animal studies. Herein we present high efficacy of treating late-stage systemic anthrax with Doxycycline as a monotherapy or in combination with Levofloxacin in NHP.
