Clindamycin demonstrates clinical effectiveness for severe M1UK Streptococcus pyogenes pneumonia: A case report and in vitro evidence of notable antitoxin effects on M1UK

  1. Masayoshi Ezaki
  2. Tien Manh Nguyen
  3. Hitoshi Kawasuji
  4. Kentaro Nagaoka
  5. Yusuke Takegoshi
  6. Kaho Ikeda
  7. Junichi Kanatani
  8. Kazunori Oishi
  9. Yoshitomo Morinaga
  10. Yoshihiro Yamamoto
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Abstract

We report a case of severe M1 UK Streptococcus pyogenes pneumonia that treated with adjunctive clindamycin therapy. In vitro, clindamycin consistently suppressed streptococcal pyrogenic exotoxin A ( speA ) expression in M1 UK , but not in M1 global , and levofloxacin had no suppressive effects, thus underscoring the important antitoxin role of clindamycin in M1 UK infections.

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  1. Version published to 10.21203/rs.3.rs-8283372/v2 on Research Square
  2. Version published to 10.21203/rs.3.rs-8283372/v1 on Research Square