Circulating prothymosin alpha and immunoglobulin G3 in acute rheumatic fever and rheumatic heart disease: A case-control study
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The lack of specific diagnostic tests for acute rheumatic fever (ARF) and its consequence rheumatic heart disease (RHD) is a key barrier to effective control of these diseases in low resource settings. Prothymosin alpha (PTA) and immunoglobulin G3 (IgG3) have recently been proposed as ARF biomarkers, although studies of these markers have so far been limited to single populations. Consequently, we evaluated PTA and IgG3 in patients with ARF, RHD and controls from studies set in Pakistan and Uganda.
