Cytokines IL-1β, TNF-α, and IL-10 as Possible Biomarker Molecules Predictive of Sepsis
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Introduction
sepsis causes a high percentage of morbidity and mortality in patients treated in the ICU, it is a complex pathology both in its definition and in its pathophysiology, with major anachronisms in the diagnosis, based on signs, symptoms and laboratory data that do not provide sufficient information to direct treatment, for this reason it is necessary to implement a diagnostic method to determine the patient’s septic and prognostic status.
Objective
to determine the expression of the cytokines IL-1, TNF and IL-10 in patients admitted to the Intensive Care Unit (ICU) of a Hospital in Montería, Córdoba.
Materials and methods
descriptive study, with 40 ICU patients who met the inclusion criteria. The serum levels of the cytokines were measured with Elisa and the results were analyzed with GraphPad Prism 6, applying the U Mann Whitney test for non-parametric data.
Results
the plasma IL-10 concentration was of great relevance in septic patients, being elevated in the pulmonary focus, the main generator of sepsis.
Conclusion
the cytokine IL-10 was considered a possible predictor of mortality in patients with sepsis.
