Predictive value of macrophage inflammatory protein 3β in the risk of death in sepsis patients

Purpose This study aims to explore the predictive value of macrophage inflammatory protein 3β (MIP-3β) for mortality risk in sepsis patients. Methods 177 sepsis patients visited the emergency medicine department of Beijing Chaoyang Hospital between October 2020 and April 2021. Within an hour of admission, serum levels of WBC (white blood cell), PLT (platelet), TBIL (total bilirubin), PCT (procalcitonin), CRP (C-reactive protein), and MIP-3β were measured, and patients were assessed with organ failure scores—SOFA (Sequential Organ Failure Assessment) and APACHE II (Acute physiology and chronic health evaluation) scores. Logistic regression was used to predict independent risk factors for 28-day mortality, and Receiver Operating Characteristic (ROC)curves were used to assess predictive value. Results MIP-3β, SOFA, and APACHE II scores were statistically different ( P  < 0.05) between the survival and death groups. The logistic regression analysis revealed that the MIP-3β, SOFA, and APACHE II scores were independent risk factors for 28-day mortality ( P  < 0.05) in sepsis patients. The area under the ROC curve (AUC) for the MIP-3β area was 0.635 (sensitivity 0.573, specificity 0.679, critical value 93.43), which was slightly lower than that of the SOFA score 0.839 (sensitivity 0.573, specificity 0.962, critical value 7.5, Z  = 3.446, P  = 0.0006) and APACHE II score 0.773 (sensitivity 0.556, specificity 0.925, critical value 21.5, Z  = 2.304, P  = 0.0212); however, the combined prediction using MIP-3β and SOFA scores (AUC area 0.86, sensitivity 0.637, specificity 0.981, Z  = 4.552, P  < 0.0001) had higher AUC area, sensitivity, and specificity than MIP-3β alone. Conclusions MIP-3β, SOFA, and APACHE II scores were independent risk factors for 28-day mortality in sepsis patients. The predictive value of MIP-3β combined with SOFA score was higher than that of MIP-3β alone, which is crucial for reducing mortality in sepsis patients.