EBV-positive Hodgkin lymphoma with immunosuppressive microenvironment during IL-23 inhibitor therapy for psoriasis

  1. Bhaumik Shah
  2. Janusz Franco-Barraza
  3. Kathy Q. Cai
  4. Mariia Dmitrieva
  5. Marcus Messmer
  6. Yibin Yang
  7. Mariusz Wasik
  8. Edna Cukierman
  9. Reza Nejati
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Abstract

We report the initial case of EBV-positive classic Hodgkin lymphoma (cHL) after guselkumab therapy for psoriasis. High-plex spatial proteomic analysis showed a Th2-polarized immunosuppressive tumor microenvironment, indicating immune reprogramming from IL-23 inhibition might have triggered the onset of EBV-positive cHL.

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  1. Version published to 10.1101/2025.04.08.25325422v1 on medRxiv