Resolving tissue-level proteomic complexity in cutaneous squamous cell carcinoma (cSCC) with ultra high-plex spatial profiling

  1. Rahul Ladwa
  2. Meg L Donovan
  3. Naomi Berrell
  4. Kidane Embaye
  5. Tony Blick
  6. Alexa E Lasley
  7. Margaret L Hoang
  8. Terence C Theisen
  9. Joseph M Beechem
  10. Chin Wee Tan
  11. Arutha Kulasinghe
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Abstract

Immune-checkpoint inhibitors (ICIs) are the primary treatment for advanced cutaneous squamous cell carcinoma (cSCC). Tumour microenvironment differences between immunocompetent and immunocompromised patients may underpin the development of effective biomarkers. Across 4 cSCC patients, we profiled 190 consecutively gridded, pathology assigned, regions of interest, using the GeoMx Discovery Protein Atlas (1116 protein markers). Expression profiles underscored by metabolic and immunological activity, including type I interferon signalling, differentiate patient immune competency.

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  1. Version published to 10.21203/rs.3.rs-8245885/v1 on Research Square