AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Synchronizing protein structure predictions with sequence databases is crucial for their accuracy. We developed AlphaSync ( alphasync.stjude.org ), a pipeline and database that provides updated AlphaFold structure models for currently 39,961 UniProt proteins, including isoforms. Moreover, AlphaSync enhances 2.6 million structures with residue-level features, including solvent accessibility, dihedral angles, intrinsic disorder predictions, and 4.7 billion atom-level noncovalent contacts. AlphaSync’s user-friendly interface enables structural analyses at scale across up-to-date proteomes for 42 species.
