Impact of JN.1 booster vaccination on neutralisation of SARS-CoV-2 variants KP.3.1.1 and XEC

  1. Prerna Arora
  2. Christine Happle
  3. Amy Kempf
  4. Inga Nehlmeier
  5. Metodi V. Stankov
  6. Alexandra Dopfer-Jablonka
  7. Georg M. N. Behrens
  8. Stefan Pöhlmann
  9. Markus Hoffmann
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Abstract

The SARS-CoV-2 KP.3.1.1 lineage is currently the dominating lineage on several continents. In parallel, the XEC lineage, a recombinant of KS.1.1 and KP.3.3, is on track of becoming the next dominant lineage in Europe and North America. Here we performed a rapid virological characterisation of the XEC lineage and studied the impact of JN.1 mRNA booster vaccination on KP.3.1.1 and XEC neutralisation.

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  1. Version published to 10.1101/2024.10.04.616448v1 on bioRxiv