Assessing genome conservation on pangenome graphs with PanSel
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Motivation
With more and more telomere-to-telomere genomes assembled, pangenomes make it possible to capture the genomic diversity of a species. Because they introduce less biases, pangenomes, represented as graphs, tend to supplant the usual linear representation of a reference genome, augmented with variations. However, this major change requires new tools adapted to this data structure. Among the numerous questions that can be addressed to a pangenome graph is the search for conserved regions, i.e. genomic that are likely retained during evolution.
Results
In this article, we present a new tool, named PanSel, which finds genomic regions that are significantly conserved, or divergent.
Availability
PanSel, written in C++11 with no dependency, is available at https://github.com/mzytnicki/pansel .