Virological traits of the SARS-CoV-2 BA.2.87.1 lineage

  1. Lu Zhang
  2. Alexandra Dopfer-Jablonka
  3. Inga Nehlmeier
  4. Amy Kempf
  5. Luise Graichen
  6. Noemí Calderón Hampel
  7. Anne Cossmann
  8. Metodi V. Stankov
  9. Gema Morillas Ramos
  10. Sebastian R. Schulz
  11. Hans-Martin Jäck
  12. Georg M. N. Behrens
  13. Stefan Pöhlmann
  14. Markus Hoffmann
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Abstract

The highly mutated SARS-CoV-2 BA.2.87.1 lineage was recently detected in South Africa, but its transmissibility is unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for high transmissibility.

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  1. Version published to 10.1101/2024.02.27.582254v1 on bioRxiv