Real-time monitoring of the effectiveness of six COVID-19 vaccines in Hungary in 2021 using the screening method
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- Evaluated articles (ScreenIT)
Abstract
Several studies have reported a waning of the effectiveness of COVID-19 vaccines. We report real-life vaccine effectiveness in Hungary, estimated with the screening method, in 2021, i.e., covering the dominance of both the Alpha and the Delta variant, and including the booster roll-out. Hungary is in the unique position to use six different vaccines (including the Sputnik V and Sinopharm vaccines, for which limited evidence was available prior to the present study) in the same, relatively homogeneous population. All vaccines provided high level of protection initially which declined over time. While the picture is different in each age group, the waning of immunity is apparent for all vaccines and especially in the younger age groups and the Sinopharm, Sputnik-V and AstraZeneca vaccines, which performed similarly. This is clearly reversed by booster doses, more prominent for those vaccines, where recipients were more likely to take the booster dose (which were the aforementioned three vaccines). Booster doses were almost exclusively mRNA vaccines. Overall, two vaccines, Pfizer/BioNTech and Moderna tend to produce the best results in all age groups, and even with waning taken into account.
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SciScore for 10.1101/2022.02.18.22271179: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The most important limitation of the present study – in addition to every intrinsic limitation of the screening method itself, especially its particular susceptibility to confounding – is the lack of case-based vaccination data on the receipt of the third those, therefore the inability to control for it. The second most important limitation is the unavailability of vaccine coverage statistics by more specific risk factors that would …
SciScore for 10.1101/2022.02.18.22271179: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The most important limitation of the present study – in addition to every intrinsic limitation of the screening method itself, especially its particular susceptibility to confounding – is the lack of case-based vaccination data on the receipt of the third those, therefore the inability to control for it. The second most important limitation is the unavailability of vaccine coverage statistics by more specific risk factors that would allow for more stratification of VE. Selection bias (e.g. enhanced testing for COVID-19 among people with underlying chronic conditions), observer bias (e.g. vaccinated cases might be less likely swabbed) or underreporting also cannot be ruled out in the national surveillance data collection. Moreover, potential confounders such as chronic underlying diseases are not reported, so adjusting for them is not possible. To reduce the impact of uncontrolled confounding, we calculated VE in an age-specific manner, as age is correlated with the presence of comorbidities. As for any VE study, results might be influenced by the fact that part of the unvaccinated are protected due to prior infection which is not accounted for. This would result in an underestimation of VE, mitigated by the fact that vaccinated also partly gain protection from prior infection. We had no information on the completeness of linkage between the database on infections and on vaccinations (i.e., how often a missing vaccination data indicates failure to link and not true unvaccinate...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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