Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission

  1. Jenni Virtanen
  2. Kirsi Aaltonen
  3. Kristel Kegler
  4. Vinaya Venkat
  5. Thanakorn Niamsap
  6. Lauri Kareinen
  7. Rasmus Malmgren
  8. Olga Kivelä
  9. Nina Atanasova
  10. Pamela Österlund
  11. Teemu Smura
  12. Antti Sukura
  13. Tomas Strandin
  14. Lara Dutra
  15. Olli Vapalahti
  16. Heli Nordgren
  17. Ravi Kant
  18. Tarja Sironen

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Abstract

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that minks remain virus RNA positive for days, develop clinical signs and histopathological changes, and transmit the virus to uninfected recipients warranting further studies and preparedness.

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  1. Version published to 10.1101/2022.02.16.480524v2 on bioRxiv
  2. ScreenIT

    SciScore for 10.1101/2022.02.16.480524: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

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  3. Version published to 10.1101/2022.02.16.480524v1 on bioRxiv