Cholesterol determines the cytosolic entry and seeded aggregation of tau

  1. Benjamin J. Tuck
  2. Lauren V.C. Miller
  3. Taxiarchis Katsinelos
  4. Annabel E. Smith
  5. Emma L. Wilson
  6. Sophie Keeling
  7. Shi Cheng
  8. Marina J. Vaysburd
  9. Claire Knox
  10. Lucy Tredgett
  11. Emmanouil Metzakopian
  12. Leo C. James
  13. William A. McEwan

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Abstract

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  1. Version published to 10.1016/j.celrep.2022.110776
  2. preLights

    Excerpt

    Tau aggregation in AD: Changes in cholesterol are shown to affect entry of tau into the cytosol in neurones and human cell lines.

  3. Version published to 10.1101/2021.06.21.449238 on bioRxiv