Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length
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Abstract
The risk factors for development of fibrotic-like radiographic abnormalities after severe COVID-19 are incompletely described and the extent to which CT findings correlate with symptoms and physical function after hospitalisation remains unclear. At 4 months after hospitalisation, fibrotic-like patterns were more common in those who underwent mechanical ventilation (72%) than in those who did not (20%). We demonstrate that severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission and leucocyte telomere length are independent risk factors for fibrotic-like radiographic abnormalities. These fibrotic-like changes correlate with lung function, cough and measures of frailty, but not with dyspnoea.
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SciScore for 10.1101/2021.03.17.21253834: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of this study include its small size, the lack of replication cohort, and the possibility that COVID-19 may itself affect telomere length. Our primary outcome, ILA, may precede COVID infection. Patients were …
SciScore for 10.1101/2021.03.17.21253834: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of this study include its small size, the lack of replication cohort, and the possibility that COVID-19 may itself affect telomere length. Our primary outcome, ILA, may precede COVID infection. Patients were hospitalized prior to FDA-approved therapies, yet half received steroids. Still, this study reveals significant respiratory symptoms and morbidity associated with severe COVID-19. Dyspnea, as noted by most survivors14, correlates more strongly with muscle strength and frailty than ILAs, suggesting persistent multisystemic dysfunction. Additional prospective studies are needed to characterize temporal changes of post-COVID-19 fibrotic abnormalities, and clinical trials are needed to investigate therapeutic options to promote its resolution.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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