Long-Term Duration of Antibody Response to SARS CoV-2 in One of the Largest Slums of Buenos Aires
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Abstract
The durability of the antibody response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has not been fully elucidated. We have performed a cross-sectional study in one of the largest slums of Buenos Aires, Barrio Padre Mugica in June 2020, detecting a seroprevalence of 53.4%. To evaluate the persistence of the humoral response against SARS-CoV-2 in this area, we designed a second study assessing only the people that were IgG positive in the first survey. The IgG levels against the full spike (S) protein in 175 individuals that were seropositive, at least 6 months before, were evaluated in a second survey. The positivity rate was 92.0%, 161 from 175 individuals remained IgG positive. We observed a contraction in the overall IgG levels measured by ELISA. The median IgG dropped 62% from June to December 2020. Most of the individuals tested (87%) reported to be asymptomatic or oligo-symptomatic. No difference was found between men and women, but people aged less than 50 showed a lower IgG level in each period compared to older individuals. Our data indicate sustained humoral immunity for at least 6 months in a specific socio-economical setting in a population that was mainly asymptomatic for COVID-19.
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SciScore for 10.1101/2021.03.05.21253010: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics statement: The study was approved by the institutional review board of the “Hospital de Niños, Dr. Ricardo Gutierrez”, Argentina.
Consent: Informed consent was obtained from every participant.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Significant level was set in 0.05 and statistical analysis was performed with software R version 4.0.2 Funding source: The National and local Ministries of Health provided medical supplies for the survey and for the virology laboratory to perform the ELISA test for SARS-COV-2 antibodies detection. SARS-CO…SciScore for 10.1101/2021.03.05.21253010: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics statement: The study was approved by the institutional review board of the “Hospital de Niños, Dr. Ricardo Gutierrez”, Argentina.
Consent: Informed consent was obtained from every participant.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Significant level was set in 0.05 and statistical analysis was performed with software R version 4.0.2 Funding source: The National and local Ministries of Health provided medical supplies for the survey and for the virology laboratory to perform the ELISA test for SARS-COV-2 antibodies detection. SARS-COV-2suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04673279 Recruiting Long-term COVID-19 Immune Response in a Vulnerable Neighbour… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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