Antimicrobial Resistance Patterns and Multidrug-Resistant Uropathogens from Urinary Tract Infections in Dhaka City: A Retrospective Cross-Sectional Study
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This retrospective study investigates the prevalence and antibiotic resistance patterns of uropathogens isolated from urinary tract infections (UTIs) in a tertiary care hospital in Dhaka, Bangladesh. A total of 5,662 urine samples from suspected UTI patients between February 2024 and February 2025 were analyzed. Out of these, 1,574 (28%) cases were culture positive, with a notable 60.61% of infections occurring in females. Gram-negative bacteria predominated, with Escherichia coli (42%) and Klebsiella spp. (25%) identified as the most prevalent uropathogens. Among Gram-positive isolates, Enterococcus spp. (7%) was most frequent. Antimicrobial susceptibility testing revealed substantial resistance to cephalosporins and fluoroquinolones among the majority of isolates. Alarmingly, the study revealed frequent occurrence of multidrug resistance (MDR) and extensive drug resistance (XDR), with 37% of isolates classified as MDR and 9% as XDR. Notably, a significant association was found between sex and XDR Proteus spp. infections (p < 0.01), although age did not show a similar correlation. These findings underscore the increasing burden of antimicrobial resistance among uropathogens in Bangladesh. The findings also emphasize the critical need for enhanced surveillance, judicious antibiotic use, and the development of targeted treatment strategies to address the rising threat of antimicrobial resistance in UTIs in Bangladesh.
