Surprise - Another Carbapenemase! Limited Options, Unexpected Resistance: Tandem Guiana Extended Spectrum Beta Lactamases in Difficult-to-Treat Pseudomonas aeruginosa

  1. Rachel Brittany Sidebottom
  2. Jorge E. Lara-Endara
  3. Leslie Huggins
  4. William Johnson
  5. Amer El Ghali
  6. Daryl Domman
  7. Meghan Brett

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Abstract

We report a case of a patient recently hospitalized outside the United States who developed Pseudomonas aeruginosa infection with difficult-to-treat resistance. Whole-genome sequencing (WGS) identified tandem Guiana extended-spectrum beta-lactamases (blaGES-19/20). We highlight WGS value and the infection-control and pharmacy challenges of managing uncommon resistance in practice.

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  4. Version published to 10.1099/acmi.0.001216.v1 on Access Microbiology