Genome sequences of Streptomyces diastaticus DSM 41029, Streptomyces violaceoruber DSM 41013 and Streptomyces griseoincarnatus DSM 41036 and reclassification of Streptomyces tunisiensis

In this study, three Streptomyces strains (DSM 41013, DSM 41029, and DSM 41036) were subjected to taxogenomic and genome mining for biosynthetic gene clusters (BGCs). The strains had genome sizes of 8.7, 6.9, and 7.9 Mb, with GC contents of 72.0, 73.5, and 72.0%, respectively. Genome BLAST distance phylogeny, digital DNA-DNA hybridization (dDDH) and average nucleotide identity (ANI), confirmed the assignment of the strains to Streptomyces violaceoruber, Streptomyces diastaticus, and Streptomyces griseoincarnatus species, respectively. These analyses also support the reclassification of Streptomyces tunisiensis as a later heterotypic synonym of Streptomyces griseoincarnatus. Accordingly, an emended description of S. griseoincarnatus is provided. Genome mining revealed the presence of multiple classes of BGCs, highlighting their biosynthetic potential. This study provides insights into intraspecies diversity within the genus Streptomyces and underscores its biotechnological potential, though further functional and experimental analyses are required