Reactive Infectious Mucocutaneous Eruption secondary to Chlamydia pneumoniae infection in a 19-year-old

Introduction Reactive Infectious Mucocutaneous Eruption (RIME) is a phenomenon that occurs predominantly in children and young adults following a bacterial or viral respiratory infection. While RIME is most associated with Mycoplasma pneumoniae, it has rarely been described with other respiratory pathogens. Case Report An otherwise healthy 19-year-old male presented with cough, fever, conjunctivitis, oral mucositis with ulceration preventing food intake, and dysuria. Chlamydia pneumoniae was detected on nasopharyngeal swab by PCR while broad workup of alternative infectious and autoimmune causes was unremarkable. Despite supportive care, antibiotics, and initial steroid treatment, his mucositis necessitated hospital admission and eventually steroid regimen intensification before fully resolving. Conclusion Chlamydia pneumoniae should be considered as a possible trigger of RIME in adolescents and young adults. Treatment involves supportive care, antibiotics and steroids if RIME symptoms are severe.