Plasma Metagenomic Cell-Free DNA Sequencing Identifies Clinically Unsuspected Cases of Toxoplasma gondii Infection in Immunocompromised Patients
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Toxoplasmosis is challenging to diagnose. Here we describe eight cases of T. gondii infections identified in immunocompromised hosts by plasma metagenomic cell-free deoxyribonucleic acid (cfDNA) sequencing, including five clinically unsuspected cases, and review the potential for plasma cfDNA sequencing to expand the diagnosis of toxoplasmosis in diverse clinical presentations.
