Infection caused by a cryptic fungal species, Blastomyces gilchristii, in a tiger
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Blastomycosis is a serious fungal disease affecting humans and animals. It is typically caused by the thermally dimorphic fungus, Blastomyces dermatitidis. In this report, we describe an infection caused by the cryptic fungal species, Blastomyces gilchristii, in a tiger (Panthera tigris).
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The reviewers have highlighted minor concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
This is a simple perhaps interesting report of a tiger that succumbed by a yeast infection caused by Blastomyces gilchristii. As this is uncommon, manuscript can be accepted. I have only a few remarks. L65 - If available, data on drug therapy should be provided (dosage, duration of treatment, via…) Some typo errors are seen throughout the manuscript Examples: "changes(Pullen"; "35ºC" "15-25um" Scientific names need to be written italicized (L44). L81 - There were more than one isolate? Fig 1 - Provide a bar size and/or magnification for B and D. Could the authors improve Figure D image?
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you …
Comments to Author
This is a simple perhaps interesting report of a tiger that succumbed by a yeast infection caused by Blastomyces gilchristii. As this is uncommon, manuscript can be accepted. I have only a few remarks. L65 - If available, data on drug therapy should be provided (dosage, duration of treatment, via…) Some typo errors are seen throughout the manuscript Examples: "changes(Pullen"; "35ºC" "15-25um" Scientific names need to be written italicized (L44). L81 - There were more than one isolate? Fig 1 - Provide a bar size and/or magnification for B and D. Could the authors improve Figure D image?
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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Comments to Author
This is an interesting and well-presented case that highlights an important aspect of microbiology and the evolving epidemiology of infectious diseases. The manuscript is clearly written, with a well-described case and an unambiguous diagnosis. Both the results and discussion are logically structured and easy to follow. Minor Questions/Recommendations: Does the urinary antigen test used detect B. gilchristii, or only B. dermatitidis? Is there data in the literature addressing this? Clarifying this could add depth to the discussion, particularly regarding the interpretation of historical data. The discussion contains some minor repetition in the early paragraphs regarding differences between Blastomyces species (e.g., lines 116/117 and 131/132; 112/113 and 127-130). Slight rewording could help …
Comments to Author
This is an interesting and well-presented case that highlights an important aspect of microbiology and the evolving epidemiology of infectious diseases. The manuscript is clearly written, with a well-described case and an unambiguous diagnosis. Both the results and discussion are logically structured and easy to follow. Minor Questions/Recommendations: Does the urinary antigen test used detect B. gilchristii, or only B. dermatitidis? Is there data in the literature addressing this? Clarifying this could add depth to the discussion, particularly regarding the interpretation of historical data. The discussion contains some minor repetition in the early paragraphs regarding differences between Blastomyces species (e.g., lines 116/117 and 131/132; 112/113 and 127-130). Slight rewording could help tighten the flow and avoid redundancy. This is a minor issue but worth considering for readability.
Please rate the quality of the presentation and structure of the manuscript
Very good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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