Detection of vanA genes in vancomycin-susceptible Enterococcus faecium isolates: implications for additional testing
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To assess the frequency of silent vancomycin resistance, phenotypically susceptible Enterococcus faecium isolates underwent genotypic testing using Cepheid’s Xpert vanA / vanB PCR. A total of 6% of isolates had silent vanA genes. However, the clinical relevance of silent van genes and the lack of rapid, random-access genotypic methods poses an ongoing challenge to laboratories.