Campylobacter fetus subsp. fetus: an unforeseen cause of abortion in regional Australia
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Campylobacter fetus (C. fetus) subsp. fetus, a Gram-negative bacterium, is an established cause of abortion and infertility in cattle, sheep and goats. Human infections have been rarely reported. In contrast to TORCH infections, this Campylobacter species is hardly recognized as a cause of abortion in humans. Since 1947 after the first case report in France, there have been only 11 reported cases of pregnant women worldwide and no published reports in Australia, pregnant or otherwise. The case in this study was compared to the first reported infection of C. fetus in 1947 to raise awareness and educate doctors and midwives, subsequently impacting prenatal and antenatal counselling in these regions. A Venn diagram was constructed to highlight the similarities between this and the index case. The similarities found included the clinical state of the patient post-abortion and the all-important history of exposure to farm animals that suffered recent deaths on the farms of both patients. Some of the differences included the time of onset of symptoms to the time of abortion, the choice of antibiotics by both treating teams and the presentation of sepsis, suggesting the importance of C. fetus subsp. fetus as a perinatal infection.
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I am pleased to tell you that your article has now been accepted for publication in Access Microbiology.
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Many thanks for your work! The manuscript has been substantially improved, well done. However, the reviewer has raised some minor issues which can be corrected during a re-write. I have issued a Major Revise however as concerns regarding Ethical Approval were noted, which I had unfortunately missed during my initial assessment. As stated by the reviewer, there is a difference between Ethical Approval to conduct research and Informed Consent. While patients would have provided their consent to be enrolled in your study, was the study reviewed by any Ethics Committee? This is a requirement for most research studies involving human participants. Now, it may be a case where a formal review by an Ethics Committee was not required and an application for Ethical Approval was waived; if that was the case then this should also be explicitly …
Many thanks for your work! The manuscript has been substantially improved, well done. However, the reviewer has raised some minor issues which can be corrected during a re-write. I have issued a Major Revise however as concerns regarding Ethical Approval were noted, which I had unfortunately missed during my initial assessment. As stated by the reviewer, there is a difference between Ethical Approval to conduct research and Informed Consent. While patients would have provided their consent to be enrolled in your study, was the study reviewed by any Ethics Committee? This is a requirement for most research studies involving human participants. Now, it may be a case where a formal review by an Ethics Committee was not required and an application for Ethical Approval was waived; if that was the case then this should also be explicitly stated. I would advise you to discuss with your local Ethics Committee.
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Comments to Author
1.Title:Subspecies Fetus, the F in fetus should be a small letter f as in fetus 2. Abstract: i.In line 29, remove there have been . The sentence would be better with" Since 1947 after the first case report in France, there are only 11 reported cases in pregnant women worldwide and no published reports in Australia, pregnant or ....... ii There is need to mention your outcome in the abstract note an abstract captures a brief introduction, methodology, and results. 3. Introduction:i In line 50, remove "our" and replace with "the" 4. Findings are your Results so replace the subtitle findings with results . The contents of the subtitle "Results should be taken bellow line 145 paragraph of discussion. You can see that it explains your results ii In line 90 Vincent Dumas, there is no year and et …
Comments to Author
1.Title:Subspecies Fetus, the F in fetus should be a small letter f as in fetus 2. Abstract: i.In line 29, remove there have been . The sentence would be better with" Since 1947 after the first case report in France, there are only 11 reported cases in pregnant women worldwide and no published reports in Australia, pregnant or ....... ii There is need to mention your outcome in the abstract note an abstract captures a brief introduction, methodology, and results. 3. Introduction:i In line 50, remove "our" and replace with "the" 4. Findings are your Results so replace the subtitle findings with results . The contents of the subtitle "Results should be taken bellow line 145 paragraph of discussion. You can see that it explains your results ii In line 90 Vincent Dumas, there is no year and et al should be italicized. iii In line 93, remove" our" and replace with either " this" or present 5. In line 122, insert a full stope after [55]. 6. Conclusion: Remove lines 259n to mother and fetus in 162. Ratheer State" This research revealed Campylobacter fetus subspecies fetus in both the mother and the fetus. This bacterium is well established as a 7 Remove "We: in line 167 and rephrase. Note: There is a diffrence between Ethical Approval and Consent to participate. Informed consent is obtained from the subjects who agree for sample collections.While ethical approval is granted by either Ministry of Health in State, a teaching university ethical committee etc. It is reqjuired for all researches involving samples collection from humans and animals.Please regularise 8 Please format your reference .
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Partially support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
No: There is no evidencde of ethical approval, authors emphasized on informed consent which is different from ethical approval
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While your research subject remains important and relevant, your manuscript requires a thorough revision. Please address the reviewer's comments. Please feel free to reach out to myself for any queries, I would be happy to assist. The reviewers have highlighted major concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
Abstract -In line 31, avoid the use of we, I, Us, in scientific Report. Rephrase the sentence. eg, The case in this study was compared ......... ,Compare should be compared in pass tense. Additionally summarize the comparison made with the 1947 case. The abstract should contain a statement for conclusion (Summary of Your findings). Introduction: In line 35, when you use bacterium, then use specie not species, similarly, In line 36, use This specie has two subtypes rather than this species. In line 37, begin the new sentence with Campylobacter fetus not C. fetus. Merge Introduction into one paragraph. There are no citations in the whole of the introduction. This has given room to plagiarism. There should be a citation at the end of each sentence according to the journal's authors instruction. Line …
Comments to Author
Abstract -In line 31, avoid the use of we, I, Us, in scientific Report. Rephrase the sentence. eg, The case in this study was compared ......... ,Compare should be compared in pass tense. Additionally summarize the comparison made with the 1947 case. The abstract should contain a statement for conclusion (Summary of Your findings). Introduction: In line 35, when you use bacterium, then use specie not species, similarly, In line 36, use This specie has two subtypes rather than this species. In line 37, begin the new sentence with Campylobacter fetus not C. fetus. Merge Introduction into one paragraph. There are no citations in the whole of the introduction. This has given room to plagiarism. There should be a citation at the end of each sentence according to the journal's authors instruction. Line 50 should be Methodology, then line 51 Case Presentation under methodology Clearly seperate methodology and results Line 73 titled "Investigation" differs from its contains in lines from 74 to 89.The contents of these lines seams to be summary of findings.THE LABORATORY activity carried out should be stated under methodology while this outcome under results Figure 1. Figure 2 and all tables should be under the subtitle "results". Please describe the contents of each in short paragraph. eg. Figure 1. is a comparison of ....and 1947..... Table 2 revealed.......etc. In a research of this nature, there should be a clear and explicit methodology , results, discussion and conclusion as subheadings. No citation on methodology used. Whose methods did you used. Line 98-104 should be taken to methodology. Please Note. A research methodology is an outline of the step by step procedure used in carrying out a research with citations in most cases. The findings in those procedures are then summarized under a subhead "Results),.You can make your comparison of the findings in this research with the first case of 1947 in your results presentation so that discussion can be clear Your discussion is too short, After a brief introduction, of discussion, attention of discussion should be based on findings. The discussion should compare findings to that of 1947 stating similarities and differences suggesting reasons thereof. Discuss the tables and figures in comparison with the findings of 1947 Conclusion In line 131, the name of animal researched on is not mentioned, this is important, In line 136, We aim.... should not appear at all rather. The aim of the research should have been stated at the aim of Introduction Contributions of authors, you wrote: Conceptualization: IOA. Collected consent and data: IOA. Writing original draft: IOA,MR,NJ.this can be rephrase as Conceptualization, collection of consent and data ,initiation of write-up or draft IOA, then state the role played by MR and NJ. There is improvement over initial submission. Kindly revise for the better
Please rate the quality of the presentation and structure of the manuscript
Poor
To what extent are the conclusions supported by the data?
Partially support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
Yes: The write up is poorly cited. No citations in the introduction and methodology. These gives room to plagiarism
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
No: There is no evidence of ethical process neither is there supporting statement for it in the methodology
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The reviewers have highlighted major concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
1.TTITLE.Campylobacter fetus subspecies fetus should be italicized. 2.ABSTRACT: Scientific abstract should not carry citations.(in 1947, R. Vincent, Dumas and Picard...).Kindly rewrite with a brief background of title/subject , methodology results and conclusion. The abstract is a summary of the whole write up.All Campylobacter should begin a with capital letter C while fetus begins with small letter f. INTRODUCTION: a).Avoid using pronouns like "we, I, etc. in scientific reports. b).Your introduction is out of authors' instructions.l. c) Your introduction is a combination of methodology " eg. A full septic workup, serology, and coagulation studies were conducted during the infective stage. and results e.g.Post-mortem examination of the fetus revealed no dysmorphism. Microarray, chromosomal …
Comments to Author
1.TTITLE.Campylobacter fetus subspecies fetus should be italicized. 2.ABSTRACT: Scientific abstract should not carry citations.(in 1947, R. Vincent, Dumas and Picard...).Kindly rewrite with a brief background of title/subject , methodology results and conclusion. The abstract is a summary of the whole write up.All Campylobacter should begin a with capital letter C while fetus begins with small letter f. INTRODUCTION: a).Avoid using pronouns like "we, I, etc. in scientific reports. b).Your introduction is out of authors' instructions.l. c) Your introduction is a combination of methodology " eg. A full septic workup, serology, and coagulation studies were conducted during the infective stage. and results e.g.Post-mortem examination of the fetus revealed no dysmorphism. Microarray, chromosomal analysis, and placental histopathology were normal Note: Rewrite introduction by briefly giving a background for C.fetus, and other causes of septic abortions including relevant literatures on the subject stating clearly the gaps you intend fill. MMETHODOLOGY:Clearly organize your write up into Introduction, Methodology, Results and Discussions. The methodology should carry a step by step procedure of how you carried out the research in a reported speech, the results should be a description of the outcome then in tables, charts or graphs. DISCUSSION Campylobacter fetus, a gram-negative bacterium, is one of the most under recognized species.This should be in the introduction not discussion.You didnt discuss the findings rather the whole of your discussion should be Introduction. Please rewrire.
Please rate the quality of the presentation and structure of the manuscript
Poor
To what extent are the conclusions supported by the data?
Partially support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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Comments to Author
Journal Name: Access Microbiology Article type: Case Report Manuscript title: Campylobacter fetus subspecies fetus; an unforeseen cause of abortion in Regional Australia. Manuscript ID: ACMI-D-24-00143 Comments for the Authors: Comment-1: I appreciate the opportunity to review this manuscript. In general, this case report reveals an interesting finding regarding the diagnosis of campylobacter fetus subspecies fetus for the first time in both the mother who was suffering from febrile infection and her fetus. The manuscript has been thoroughly evaluated and determined to be publication-ready; however, some of the shortcomings that may have been addressed with better expertise are listed below: Comment-2: The bacterial scientific name for campylobacter fetus subspecies fetus and other cited bacterial …
Comments to Author
Journal Name: Access Microbiology Article type: Case Report Manuscript title: Campylobacter fetus subspecies fetus; an unforeseen cause of abortion in Regional Australia. Manuscript ID: ACMI-D-24-00143 Comments for the Authors: Comment-1: I appreciate the opportunity to review this manuscript. In general, this case report reveals an interesting finding regarding the diagnosis of campylobacter fetus subspecies fetus for the first time in both the mother who was suffering from febrile infection and her fetus. The manuscript has been thoroughly evaluated and determined to be publication-ready; however, some of the shortcomings that may have been addressed with better expertise are listed below: Comment-2: The bacterial scientific name for campylobacter fetus subspecies fetus and other cited bacterial species must be italicised, and this should be done carefully throughout the text. Comment-3: According to earlier reports, Campylobacter fetus subspecies fetus was the most common cause of abortion in various animals. Why didn't the authors emphasize previous case reports on animal abortion in the introduction section line 35? Comment-4: Line 65, What type of media that used by authors to culture the blood sample that was taken from the patient? Also, how was the diagnostic procedure carried out? Comment-5: Line 74, What type of culture media was utilized to culture the placental and foetal swabs, and what biochemical tests did the authors perform to identify the isolated bacteria? Why did not the authors use the Vitek-2 compact system approach for more confirm their diagnosis? Comment-6: Line 79, Table 1: What does WCC stand for? Is it the abbreviation for White Cell Count? To make things clearer for the reader, the authors must include the whole name rather than just the abbreviated. Comment-7: Line 82, How did the authors identify the bacteria? What kind of procedure was used? The authors must provide details on how the samples were diagnosed. Comment-8: Line 91, What concentration of azithromycin is employed to treat the patient? This antibiotic has been reported to be effective against Campylobacter fetus subspecies fetus with a typical regimen of 500 mg/d for 3 days. Comment-9: All paragraphs written in the discussion section by the authors should be structured and linked properly; it is confusing for the viewers to read three or five lines in one paragraph. Please make the sentence clearer so that those who read it is able to comprehend it. Comment-10: Kindly ensure that the references list follows the Access Microbiology style. Thank you
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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