Esophageal actinobacillosis mimicking a diverticulum in a cow: a case report
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Present case report describes a case of an atypical oesophageal actinobacillosis in an adult cow presented to the university hospital with a history of inability to drink and swallow. Clinical examination revealed a five-inch swelling in the jugular groove. Skiagram revealed the presence of a small and slightly radio opaque round growth. Exploratory surgical excision of the growth was adapted as palliative treatment and the extirpated tissue was fixed in 10% buffered formalin. Histopathological examination revealed pyogranulomatous inflammation with radiating eosinophilic club shaped bodies surrounding small colonies of coccobacilli. Gram and Ziehl-Neelsen stains confirmed the presence of Gram-negative and non-acid-fast coccobacilli. Histopathology confirmed the pathognomonic lesion and proved to be a modality of choice for pathologists to reach at a diagnosis of atypical oesophageal actinobacillosis in a cow. After the exhaustive search of relevant literature on atypical actinobacillosis, the authors claim this to be the second report of oesophageal actinobacillosis worldwide.
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The work presented is clear and the arguments well formed. This study would be a valuable contribution to the existing literature.
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Comments to Author
Kindly put specific headings and subheadings to your paper. Be more descriptive.
Please rate the quality of the presentation and structure of the manuscript
Poor
To what extent are the conclusions supported by the data?
Partially support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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The reviewers have highlighted minor concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
Line 67: Add the type of fluid, access and administration flow rate. Line 67-78: Add discussion of the therapeutic protocol followed in the case. Line 68: Add the dose (mg/ml), route of administration for xylazine and for the local anesthetic. What anesthetic was used? Line 74: Add the type of fluid, access route and administration flow. Line 76: Add the dose, route and composition of the multivitamin, as well as ketoprofen. Line 78: pharmacological principle of the repellent? Line 86: how big was the cut? To add. Line 91: Determine which of the figures (1,2,3 or 4). Add call to text. Line 95: Add result figure. Line 103: Add a figure of the injury site on the animal. Line 112: Splendore-Hoepelli is a common finding in other affections. Culture data, micromorphology of the isolate or molecular …
Comments to Author
Line 67: Add the type of fluid, access and administration flow rate. Line 67-78: Add discussion of the therapeutic protocol followed in the case. Line 68: Add the dose (mg/ml), route of administration for xylazine and for the local anesthetic. What anesthetic was used? Line 74: Add the type of fluid, access route and administration flow. Line 76: Add the dose, route and composition of the multivitamin, as well as ketoprofen. Line 78: pharmacological principle of the repellent? Line 86: how big was the cut? To add. Line 91: Determine which of the figures (1,2,3 or 4). Add call to text. Line 95: Add result figure. Line 103: Add a figure of the injury site on the animal. Line 112: Splendore-Hoepelli is a common finding in other affections. Culture data, micromorphology of the isolate or molecular diagnosis by PCR are necessary to confirm histopathological findings. Line 121: Include a conclusion to the case report presented. Line 145: Right or left lateral? add information. Line 151-153: Add better quality images. In Figure 2B it is not possible to view the description of the image at the size shown. Figure 2C have poor quality.
Please rate the quality of the presentation and structure of the manuscript
Poor
To what extent are the conclusions supported by the data?
Partially support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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Comments to Author
This case report describes an intriguing and rare case of esophageal actinobacillosis in a cow. The report is well-written and provides a comprehensive description of the clinical presentation, diagnostic workup, treatment, and pathology. The authors effectively detail the cow's clinical presentation and history, clearly outline the diagnostic procedures employed, including radiography and histopathology, and present high-quality histopathological images with accompanying explanations. Additionally, they engage in a discussion of potential differential diagnoses and support their findings with a thorough literature review. However, the report could be strengthened by addressing a few limitations. Firstly, a more in-depth discussion of the potential study limitations, such as the absence of bacterial …
Comments to Author
This case report describes an intriguing and rare case of esophageal actinobacillosis in a cow. The report is well-written and provides a comprehensive description of the clinical presentation, diagnostic workup, treatment, and pathology. The authors effectively detail the cow's clinical presentation and history, clearly outline the diagnostic procedures employed, including radiography and histopathology, and present high-quality histopathological images with accompanying explanations. Additionally, they engage in a discussion of potential differential diagnoses and support their findings with a thorough literature review. However, the report could be strengthened by addressing a few limitations. Firstly, a more in-depth discussion of the potential study limitations, such as the absence of bacterial culture, is warranted. Secondly, a more detailed description of the surgical technique would be beneficial for specialists. Finally, the conclusion regarding long-term outcome, which is based on limited data (no recurrence after one year), should be cautiously interpreted. To further enhance the report, the authors could consider revising the title to be more specific, such as "Esophageal Actinobacillosis Mimicking a Diverticulum in a Cow: A Case Report." Additionally, a more comprehensive literature search might be necessary to verify the claim that this is the second reported case of esophageal actinobacillosis in the veterinary literature. Furthermore, a discussion of the potential route of infection for the esophagus would be valuable. Overall, this case report makes a significant contribution to the veterinary literature on actinobacillosis. With minor revisions, the report could be even stronger and provide a more comprehensive understanding of this rare condition.
Please rate the quality of the presentation and structure of the manuscript
Very good
To what extent are the conclusions supported by the data?
Partially support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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Many thanks for your unusual Case Report. It is indeed very interesting and well presented. However, I am issuing an early, "Major Revise" on the basis that the language can be significantly improved and may benefit from a thorough proof-read. Furthermore, a number of references quoted in the text are not listed toward the end. The house reference style is Vancouver. If your article is accepted for publication, your reference lists and citations will be reformatted to fit Vancouver style; and as such, ideally, references should include a DOI to facilitate this, and to allow us to create reference links in published articles. Once these changes are considered I do think your manuscript would be better positioned to send out for Peer Review. The language used is poor, which can cause ambiguity at times. Please carefully rewrite it. We …
Many thanks for your unusual Case Report. It is indeed very interesting and well presented. However, I am issuing an early, "Major Revise" on the basis that the language can be significantly improved and may benefit from a thorough proof-read. Furthermore, a number of references quoted in the text are not listed toward the end. The house reference style is Vancouver. If your article is accepted for publication, your reference lists and citations will be reformatted to fit Vancouver style; and as such, ideally, references should include a DOI to facilitate this, and to allow us to create reference links in published articles. Once these changes are considered I do think your manuscript would be better positioned to send out for Peer Review. The language used is poor, which can cause ambiguity at times. Please carefully rewrite it. We offer a discounted translation service, Editage (https://www.editage.com/; see https://www.microbiologyresearch.org/prepare-an-article#13 for more information).
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