Prevalence of SARS-CoV-2 virus in saliva, stool, and urine samples of COVID-19 patients in Bihar, India

  1. Nupur Meghna
  2. Archana Archana
  3. Divendu Bhushan
  4. Abhyuday Kumar
  5. Asim Sarfraz
  6. Bijaya Nanda Naik
  7. Binod Kumar Pati

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Abstract

Introduction. The coronavirus illness caused by SARS-CoV-2 can cause multiple organ involvement, with varying degrees of severity. Besides inhalation as a route for transmission, feco-oral has also been proposed. Its transmission to sewage systems is a growing public health issue.

Objective. To detect SARS-CoV-2 RNA in non-respiratory samples (saliva, urine, and stool) collected from COVID-19 cases, in Bihar.

Methods. This cross-sectional observational study was conducted from January 2021 to March 2022 on human non-respiratory samples. A total of 345 samples including saliva (116), stool (97), and urine (132) were collected from 143 COVID-19 cases. Samples were analysed for SARS-CoV-2 by multiplex RT-PCR targeted against E, ORF 1ab, and RdRp genes.

Results. In this study, out of 143 cases, a total of 107 (74.8 %) were positive for SARS-CoV-2 RNA in at least one of the non-respiratory samples.

Conclusion. There is a high prevalence of SARS-CoV-2 virus in non-respiratory samples.

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  1. Version published to 10.1099/acmi.0.000693.v4 on Access Microbiology
  3. Version published to 10.1099/acmi.0.000693.v3 on Access Microbiology
  5. Version published to 10.1099/acmi.0.000693.v2 on Access Microbiology
  9. Version published to 10.1099/acmi.0.000693.v1 on Access Microbiology