Comments on Case Report: A fatal case of Aspergillus felis infection in an immunocompetent host
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This is a study that would be of interest to the field and community. All reviewer comments have been adequately addressed.
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This study would be a valuable contribution to the existing literature. The reviewers have highlighted minor concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
This short letter is a comment to a previously published case report (Case report: a fatal case of Aspergillus felis infection in an immunocompetent host, Access Microbiology, Volume 4, Issue 11), describing an unfortunate 18-year old succumbed from A. felis infection. The manuscript was well written and statements were backed by citations, bringing up a few important key points about A. felis and its pathogenesis in humans and cats. A. felis was first described in 2013 and there are few published results on this pathogen. The author proposed that this pathogen needs more attention from microbiology and clinical fellows to share more data, to unveil pathogenesis mechanisms, and to demonstrate whether certain breeds of cats are more susceptible to A. felis infecitons. Echoing the shout-out of the …
Comments to Author
This short letter is a comment to a previously published case report (Case report: a fatal case of Aspergillus felis infection in an immunocompetent host, Access Microbiology, Volume 4, Issue 11), describing an unfortunate 18-year old succumbed from A. felis infection. The manuscript was well written and statements were backed by citations, bringing up a few important key points about A. felis and its pathogenesis in humans and cats. A. felis was first described in 2013 and there are few published results on this pathogen. The author proposed that this pathogen needs more attention from microbiology and clinical fellows to share more data, to unveil pathogenesis mechanisms, and to demonstrate whether certain breeds of cats are more susceptible to A. felis infecitons. Echoing the shout-out of the author of this letter, epidemiological investigation is recommended to be performed to identify where this patient got infected since he only has a healthy dog, whether there are any other individuals also got infected with possibly milder symptoms. Since this pathogen was recently identified and our understanding is poor, a better animal model mimicking infections would help obtain more knowledge on this pathogen and its related members.
Please rate the quality of the presentation and structure of the manuscript
Very good
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
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Comments to Author
The author has written this letter as a follow-up on the recent case published by Parkes-Smith et al related to fatal Aspergillus felis rhinocerebral infection in an immunocompetent patient. The author provides inputs related to this fungal infection from a veterinary standpoint and draws on her prior published research to highlight certain points. Overall, the brief comments raised by the author provide interesting parallels between human and veterinary infections, as well as unique insights into this rare fungal infection. I have just a few comments as below. Major Comments: The author highlighted an interesting point that immunocompetent cats (particularly those of Persian-related breeds) may be predisposed to invasive fungal rhinosinusitis due to uncharacterized genetic defects or skull changes. …
Comments to Author
The author has written this letter as a follow-up on the recent case published by Parkes-Smith et al related to fatal Aspergillus felis rhinocerebral infection in an immunocompetent patient. The author provides inputs related to this fungal infection from a veterinary standpoint and draws on her prior published research to highlight certain points. Overall, the brief comments raised by the author provide interesting parallels between human and veterinary infections, as well as unique insights into this rare fungal infection. I have just a few comments as below. Major Comments: The author highlighted an interesting point that immunocompetent cats (particularly those of Persian-related breeds) may be predisposed to invasive fungal rhinosinusitis due to uncharacterized genetic defects or skull changes. Has there been any specific research related to this in veterinary medicine? It would be helpful to reference those studies. There have been limited studies in humans that have looked at the correlation between sinus cavity sizes and the occurrence of fungal balls (Michel et al DOI: 10.1111/coa.12813). Minor Comments: The author reports that Aspergillus viridinutans was isolated from rabbit feces in Frankston in 1954. It would be helpful to reference the study that this was reported in.
Please rate the quality of the presentation and structure of the manuscript
Good
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
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