Sarcina ventriculi in association with gastric ulcer: a case report
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Sarcina ventriculi is a species of Gram-positive bacteria which has been reported in patients with delayed gastric emptying as well as in association with cases of gastric ulcer and gastric carcinoma. Although it has been reported frequently in veterinary cases as a cause of fatal diseases, the exact pathogenesis in humans has yet to be identified. We report here a case of an elderly male who presented with haematemesis following which an upper gastrointestinal endoscopy was done and a gastric ulcer was revealed. Histopathological examination revealed S. ventriculi in association with the ulcer.
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Dear Pritha Acharya, Thank you for submitting the revised manuscripts and addressing reviewers questions and comments. I'm happy to now accept the manuscript, congratulations and we welcome future submissions to Access Microbiology. Best wishes, John.
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The work presented is clear and the arguments well formed. The reviewers have highlighted minor concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
1. Unify the name throughout the text - Sarcina ventriculi - Sarcina spp - Sarcina organism (if there is a reason for a different name - explain) 2. It is not stated what the endoscopic findings of the stomach and duodenum were, whether biopsies were also taken from those areas (especially considering the thickened wall - how the possibility of stomach cancer was ruled out) 3. Whether the patient had a control endoscopy and what the findings were 4. Figure 2 is not adequate, it is blurry, maybe take a picture at a higher magnification
Please rate the quality of the presentation and structure of the manuscript
Satisfactory
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, …
Comments to Author
1. Unify the name throughout the text - Sarcina ventriculi - Sarcina spp - Sarcina organism (if there is a reason for a different name - explain) 2. It is not stated what the endoscopic findings of the stomach and duodenum were, whether biopsies were also taken from those areas (especially considering the thickened wall - how the possibility of stomach cancer was ruled out) 3. Whether the patient had a control endoscopy and what the findings were 4. Figure 2 is not adequate, it is blurry, maybe take a picture at a higher magnification
Please rate the quality of the presentation and structure of the manuscript
Satisfactory
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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Comments to Author
The authors report a rare case of human Sarcina infection associated with reflux esophagitis as proofed by upper gastro-intestinal endoscopy in patient presented by hematemesis. These are rare cases and pathologists seldom report it to the clinicians. Pathologists need to be aware of this microorganism and search for it in all cases especially cases with dyspepsia. I have a few comments: Why the patient undergo colonoscopy and CT in spite of positive findings in the upper GI endoscopy?? It is better to use an arrow in pathology slide to point to the organism as not everyone is familiar with its shape.
Please rate the quality of the presentation and structure of the manuscript
Very good
To what extent are the conclusions supported by the data?
Strongly support
Comments to Author
The authors report a rare case of human Sarcina infection associated with reflux esophagitis as proofed by upper gastro-intestinal endoscopy in patient presented by hematemesis. These are rare cases and pathologists seldom report it to the clinicians. Pathologists need to be aware of this microorganism and search for it in all cases especially cases with dyspepsia. I have a few comments: Why the patient undergo colonoscopy and CT in spite of positive findings in the upper GI endoscopy?? It is better to use an arrow in pathology slide to point to the organism as not everyone is familiar with its shape.
Please rate the quality of the presentation and structure of the manuscript
Very good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
-